Selective Types of Autophagy
نویسندگان
چکیده
1Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands 2Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan 3BioScience Center, San Diego State University, San Diego, CA 92182, USA 4Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
منابع مشابه
The Cvt pathway as a model for selective autophagy.
Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting ...
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TRIM proteins contribute to selective autophagy, a process whereby cells target specific cargo for autophagic degradation. In a previously reported screen, TRIM17 acted as a prominent inhibitor of bulk autophagy, unlike the majority of TRIMs, which had positive roles. Nevertheless, TRIM17 showed biochemical hallmarks of autophagyinducing TRIMs. To explain this paradox, here, we investigated how...
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Autophagy is a catabolic multitask transport route that takes place in all eukaryotic cells. During starvation, cytoplasmic components are randomly sequestered into huge double-membrane vesicles called autophagosomes and delivered into the lysosome/vacuole where they are destroyed. Cells are able to modulate autophagy in response to their needs, and under certain circumstances, cargoes such as ...
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عنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012